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Bevacizumab, Docetaxel, and Gemcitabine Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer


A Phase II Study of Bevacizumab Plus Docetaxel and Gemcitabine in Subjects With Advanced, Previously Untreated, Non-Squamous Non-Small Cell Lung Cancer


Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy, such as docetaxel and gemcitabine hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving bevacizumab together with docetaxel and gemcitabine hydrochloride may kill more tumor cells.


This phase II trial is studying how well giving bevacizumab together with docetaxel and gemcitabine hydrochloride works in treating patients with stage IIIB, stage IV, or recurrent non-small cell lung cancer.

Study Status: Active, not recruiting


Condition Intervention Phase
Lung Cancer Biological: bevacizumab
Drug: docetaxel
Drug: gemcitabine hydrochloride
Phase 2

Verified by Nathan Pennell, MD, PhD February, 2013

Sponsored by: Nathan Pennell, MD, PhD
Information provided by: Case Comprehensive Cancer Center identifier: NCT00970684

Study Type: Interventional

Study Design: Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center
Cleveland, Ohio 44195
United States

Hillcrest Hospital, a Cleveland Clinic Hospital
Mayfield Heights, Ohio 44124
United States

Nathan Pennell, MD, PhD., Principal Investigator
Afshin Dowlati, MD., Principal Investigator

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