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Chemotherapeutic Agents in Brain/Breast


Clinical Study to Assess Entry of Chemotherapeutic Agents Into Brain Metastases in Women With Breast Cancer


Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Lapatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Studying samples of tumor tissue and blood from patients may help doctors understand how well these drugs can be carried to the brain.


More definitive knowledge of the penetration of chemotherapeutic and other agents into the brain is necessary for the future rational design of drug and drug regimens that target brain metastases. This clinical trial is studying how well capecitabine, cyclophosphamide, doxorubicin, gemcitabine, lapatinib, paclitaxel, trastuzumab, or vinorelbine penetrates brain tumors.

Study Status: Completed


Condition Intervention Phase
Breast Cancer
Metastatic Cancer
Drug: capecitabine
Drug: cyclophosphamide
Drug: doxorubicin hydrochloride
Drug: gemcitabine hydrochloride
Drug: lapatinib ditosylate
Drug: paclitaxel
Drug: vinorelbine ditartrate
Drug: Trastuzumab

Verified by Case Comprehensive Cancer Center July, 2013

Sponsored by: Case Comprehensive Cancer Center
Information provided by: Case Comprehensive Cancer Center identifier: NCT00795678

Study Type: Interventional

Study Design: Observational Model: Case-Only, Time Perspective: Prospective

Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center
Cleveland, Ohio 44195
United States

David M. Peereboom, MD., Principal Investigator
Robert Weil, MD., Principal Investigator

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