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Echocardiographic Assessment of Cardiovascular Changes in Long Term Space Flight


Echocardiographic Assessment of Cardiovascular Adaptation and Counter Measures n Microgravity




The National Space Biomedical Research Institute is interested in learning more about heart function in space. One potential problem with long duration, manned space flight is muscle loss- including loss of heart muscle. One goal of our research is to help identify why this muscle loss occurs. We are interested in patients undergoing aortic valve surgery because this procedure is performed to correct a problem with the valve that may also change heart function. This change in heart function may provide information that is useful in understanding and potentially preventing the loss of cardiac muscle in space. Three patient groups will be studied, patients having surgery for aortic regurgitation, aortic stenosis, and coronary bypass. We are planing to perform this study on 30 patients, 10 in each group. The aim of this study is to continue our ongoing study of the magnitude and predictors of the changes in size of the left ventricle following acute volume and pressure unloading as a ground-based analog for manned space flight.

Study Status: Recruiting

Roberta Palumbo, RN 216-444-8778

Condition Intervention Phase
Aortic Valve Insufficiency
Aortic Valve Stenosis
n/a N/A

Verified by The Cleveland Clinic January, 2008

Sponsored by: The Cleveland Clinic
Information provided by: The Cleveland Clinic identifier: NCT00598598

Study Type: Interventional

Study Design: Cohort, Prospective

Cleveland Clinic
Cleveland, Ohio 44195
United States

Jim Thomas, MD., Principal Investigator

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