Study:
Effect of Bedrest With and Without Exercise on Cardiac Atrophy: Synergistic Supplemental Testing With the Cleveland Clinic Bedrest Study
Rationale:
n/a
Purpose:
The purpose of this research sub-study is to determine the changes in heart function during
the bedrest period using ultrasound and MRI. This topic is important for medical care of
astronauts in space. It can enable physicians on the ground to monitor exercise protocols
that are used to prevent deconditioning-loss of strength during long space flights.
Your participation in this study would include ultrasound examinations with bicycle exercise
before, during, and after the 12-week bedrest period. MRI exams would be performed before
and after the bedrest period.
Each echo exam may last up to 1 hour. This time will be required to perform an ultrasound
examination before and during supine (lying down) bicycle exercise. The exercise period will
be approximately 10-15 minutes. The bicycle exercise will be a symptom-limited test. This
means that the test will be stopped if you experience any discomfort. An ultrasound
examination of your heart will be done to assess heart function. You will be asked to lie on
your left side on an examination table while a technician takes pictures of your heart with a
small probe that is gently pressed against your chest after applying a gel. The ultrasound
data will be processed to evaluate myocardial strain, a value that may be useful in
describing heart function.
Each MRI may last up to 1 hour. An MRI obtains body pictures created by using magnetic
energy rather than x-ray energy. To have the scan, you will lie on a table that slides into
the scanner, which is like a large tube. An MRI examination of your heart will be done to
assess heart function. You will be asked to lie still and follow simple breathing
instructions during the procedure. The MRI data will be processed to evaluate the volume of
blood being pumped by your heart, a value that may be useful in describing heart function.
Study Status: Recruiting
Recruiting:
Christine Whitman, RN 216-445-6916 whitmac@ccf.org
| Condition |
Intervention |
Phase |
|
Bedrest |
n/a |
N/A |
Verified by
The Cleveland Clinic
January, 2008
Sponsored by: The Cleveland Clinic
Information provided by: The Cleveland Clinic
ClinicalTrials.gov identifier: NCT00598494
Study Type: Interventional
Study Design: Case-Only, Prospective
Cleveland Clinic
Cleveland, Ohio 44195
United States
Jim Thomas, MD., Principal Investigator