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Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu`s Arteritis

Study:

Concurrent Pilot Studies in Giant Cell Arteritis and Takayasu`s Arteritis to Examine the Safety, Efficacy, and Immunologic Effects of Abatacept (CTLA4-Ig) in Large Vessel Vasculitis

Rationale:

n/a

Purpose:

Giant cell arteritis (GCA) and Takayasu`s arteritis (TAK) are diseases that cause swelling of the arteries in the head, neck, upper body, and arms. TAK specifically affects the aorta, the largest blood vessel in the body, and its branches. Therapies are available to improve the symptoms of GCA and TAK, but relapse often occurs, and better treatments are needed. Abatacept is a drug that interacts with certain cells in the body that are involved with GCA and TAK. This study will evaluate the effectiveness of abatacept in treating GCA and TAK and preventing disease relapse.

Study Status: Recruiting

Recruiting:
Carol A. Langford, MD MHS 216-445-6056

Condition Intervention Phase
Takayasu`s Arteritis
Giant Cell Arteritis
Drug: Abatacept
Drug: Placebo
Phase 2

Verified by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) August, 2012

Sponsored by: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Information provided by: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
ClinicalTrials.gov identifier: NCT00556439

Study Type: Interventional

Study Design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Cleveland Clinic
Cleveland, Ohio 44195
United States

Carol A. Langford, MD, MHS., Principal Investigator

This information is abridged to display results relevant only to Cleveland Clinic. To see complete record visit ClinicalTrials.gov
  Information obtained from ClinicalTrials.gov on
Link to the current ClinicalTrials.gov record.

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