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Deep Brain Stimulation for Depression


Deep Brain Stimulation of the Internal Capsule for Severe and Medically Refractory Major Depression




The purpose of this study is to learn about a new treatment for severe depression that has not improved enough despite long-term treatment with medications and behavior therapy. The new treatment is called deep brain stimulation, or DBS. In DBS, thin wires are used to carry electric current to parts of the brain that are thought to be involved in producing depression symptoms. Two wires are implanted surgically, and attached to battery packs implanted under the skin of the new chest below your collar bone.

Study Status: Completed


Condition Intervention Phase
Depression Device: Deep Brain Stimulation Phase 1/Phase 2

Verified by The Cleveland Clinic March, 2012

Sponsored by: The Cleveland Clinic
Information provided by: The Cleveland Clinic identifier: NCT00555698

Study Type: Interventional

Study Design: Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Cleveland Clinic Foundation
Cleveland, Ohio 44195
United States

Ali Rezai, MD., Principal Investigator

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