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Duloxetine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer


A Phase III Double Blind Trial of Oral Duloxetine for Treatment of Pain Associated With Chemotherapy-Induced Peripheral Neuropathy


Duloxetine may lessen peripheral neuropathy caused by chemotherapy. It is not yet known whether duloxetine is more effective than a placebo in treating peripheral neuropathy caused by chemotherapy.


This randomized phase III trial is studying duloxetine to see how well it works compared with a placebo in treating peripheral neuropathy caused by chemotherapy in patients with cancer.

Study Status: Active, not recruiting


Condition Intervention Phase
Neurotoxicity Syndromes
Peripheral Neuropathy
Unspecified Adult Solid Tumor, Protocol Specific
Drug: duloxetine hydrochloride
Other: placebo
Phase 3

Verified by Cancer and Leukemia Group B March, 2011

Sponsored by: Cancer and Leukemia Group B
Information provided by: National Cancer Institute (NCI) identifier: NCT00489411

Study Type: Interventional

Study Design: Allocation: Randomized, Control: Placebo Control, Masking: Double-Blind, Primary Purpose: Supportive Care

Cleveland Clinic Florida - Weston
Weston, Florida 33331
United States

Ellen L. Smith, PhD, ARNP, AOCN., Study Chair
Richard L. Schilsky, MD., Principal Investigator

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