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Brain Function in Young Patients Receiving Methotrexate for Acute Lymphoblastic Leukemia


A Study of Neurocognitive Function in Children Treated for ALL


Learning about the long-term effects of methotrexate on brain function may help doctors plan cancer treatment.


This clinical trial is looking at brain function in young patients receiving methotrexate for acute lymphoblastic leukemia.

Study Status: Recruiting

Clinical Trials Office - Cleveland Clinic Taussig Cancer Cente 866-223-8100

Condition Intervention Phase
Cognitive/Functional Effects
Long-term Effects Secondary to Cancer Therapy in Children
Psychosocial Effects of Cancer and Its Treatment
Genetic: microarray analysis
Genetic: polymorphism analysis
Other: laboratory biomarker analysis
Other: pharmacological study
Procedure: cognitive assessment
Procedure: diffusion tensor imaging
Procedure: management of therapy complications
Procedure: psychosocial assessment and care

Verified by Children`s Oncology Group April, 2011

Sponsored by: Children`s Oncology Group
Information provided by: National Cancer Institute (NCI) identifier: NCT00437060

Study Type: Interventional

Study Design: N/A

Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States

Naomi J. Winick, MD., Study Chair

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