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Effects of Steroids, Controlling Blood Sugar Levels, and Avoidance of Deep Anesthesia on Patient Outcomes After Major Vascular Surgery

Study:

The Effects of Corticosteroids, Glucose Control, and Depth-of-Anesthesia on Perioperative Inflammation and Morbidity From Major Vascular Surgery

Rationale:

n/a

Purpose:

The perioperative period is characterized by an intense inflammatory response marked by elevated concentrations of inflammatory markers like C-reactive protein (CRP). This response has been linked to increased perioperative morbidity and mortality. Available evidence suggests that blunting the inflammatory response to surgery might improve perioperative outcomes. The benefits from blunting the surgical stress response are likely to be greatest in the high risk patient such as those having major non-cardiac surgery.

Study Status: Active, not recruiting

Recruiting:
n/a

Condition Intervention Phase
Major Non-Cardiac Surgery Procedure: intensive glucose management
Procedure: deeper anesthetic management
Drug: placebo
Drug: Dexamethasone
Drug: conventional glucose control
Device: Lighter anesthesia group
N/A

Verified by Aspect Medical Systems July, 2010

Sponsored by: Aspect Medical Systems
Information provided by: Aspect Medical Systems
ClinicalTrials.gov identifier: NCT00433251

Study Type: Interventional

Study Design: Allocation: Randomized, Control: Placebo Control, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Cleveland Clinic Foundation
Cleveland, Ohio 44195
United States

Daniel I Sessler, MD., Study Chair
Basem Abdelmalak, MD., Principal Investigator

This information is abridged to display results relevant only to Cleveland Clinic. To see complete record visit ClinicalTrials.gov
  Information obtained from ClinicalTrials.gov on
Link to the current ClinicalTrials.gov record.

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