Study:
The Effects of Corticosteroids, Glucose Control, and Depth-of-Anesthesia on Perioperative Inflammation and Morbidity From Major Vascular Surgery
Rationale:
n/a
Purpose:
The perioperative period is characterized by an intense inflammatory response marked by
elevated concentrations of inflammatory markers like C-reactive protein (CRP). This
response has been linked to increased perioperative morbidity and mortality. Available
evidence suggests that blunting the inflammatory response to surgery might improve
perioperative outcomes. The benefits from blunting the surgical stress response are likely
to be greatest in the high risk patient such as those having major non-cardiac surgery.
Study Status: Active, not recruiting
Recruiting:
n/a
| Condition |
Intervention |
Phase |
|
Major Non-Cardiac Surgery |
Procedure: intensive glucose management
Procedure: deeper anesthetic management
Drug: placebo
Drug: Dexamethasone
Drug: conventional glucose control
Device: Lighter anesthesia group |
N/A |
Verified by
Aspect Medical Systems
July, 2010
Sponsored by: Aspect Medical Systems
Information provided by: Aspect Medical Systems
ClinicalTrials.gov identifier: NCT00433251
Study Type: Interventional
Study Design: Allocation: Randomized, Control: Placebo Control, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Cleveland Clinic Foundation
Cleveland, Ohio 44195
United States
Daniel I Sessler, MD., Study Chair
Basem Abdelmalak, MD., Principal Investigator