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A Study of Telaprevir (VX-950), Pegasys and Copegus in Hepatitis C


A Phase 2 Study of Telaprevir in Combination With Peginterferon Alfa-2a, and Ribavirin in Subjects With Genotype 1 Hepatitis C Who Have Not Achieved Sustained Viral Response With a Prior Course of Interferon Based Therapy




The PROVE3 trial is a partially double blinded, randomized, Phase 2 research study of an investigational drug, Telaprevir (VX-950) or Placebo, with peginterferon alfa-2a (Pegasys®), and ribavirin (Copegus®) in people with genotype 1 hepatitis C who have not achieved a Sustained Viral Response (SVR) with a previous treatment of interferon therapy.

Study Status: Completed


Condition Intervention Phase
Hepatitis C Drug: Telaprevir
Drug: Ribavirin
Drug: Peg-interferon Alfa-2a
Drug: Matching Placebo
Phase 2

Verified by Vertex Pharmaceuticals Incorporated June, 2011

Sponsored by: Vertex Pharmaceuticals Incorporated
Information provided by: Vertex Pharmaceuticals Incorporated identifier: NCT00420784

Study Type: Interventional

Study Design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Cleveland Clinic
Cleveland, Ohio
United States

Medical Monitor., Study Director

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