Study:
Dose Intensive Chemotherapy for Children Less Than Ten Years of Age Newly-Diagnosed With Malignant Brain Tumors: A Pilot Study of Two Alternative Intensive Induction Chemotherapy Regimens, Followed by Consolidation With Myeloablative Chemotherapy (Thiotepa and Carboplatin, With or Without Etoposide) and Autologous Stem Cell Rescue [HEAD START III]
Rationale:
Drugs used in chemotherapy work in different ways to stop the growth of tumor
cells, either by killing the cells or by stopping them from dividing. A bone marrow or
peripheral stem cell transplant using stem cells from the patient may be able to replace
blood-forming cells that were destroyed by chemotherapy. This may allow more chemotherapy to
be given so that more tumor cells are killed.
Purpose:
This phase III trial is studying how well giving combination chemotherapy with or
without etoposide followed by an autologous stem cell transplant works in treating young
patients with previously untreated malignant brain tumors.
Study Status: Active, not recruiting
Recruiting:
n/a
| Condition |
Intervention |
Phase |
|
Brain and Central Nervous System Tumors |
Drug: carboplatin
Drug: cisplatin
Drug: cyclophosphamide
Drug: etoposide
Drug: methotrexate
Drug: temozolomide
Drug: thiotepa
Drug: vincristine sulfate
Procedure: autologous bone marrow transplantation
Procedure: autologous hematopoietic stem cell transplantation
Procedure: peripheral blood stem cell transplantation
Radiation: radiation therapy |
Phase 3 |
Verified by
Children`s Hospital Los Angeles
October, 2010
Sponsored by: Children`s Hospital Los Angeles
Information provided by: National Cancer Institute (NCI)
ClinicalTrials.gov identifier: NCT00392886
Study Type: Interventional
Study Design: Primary Purpose: Treatment
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States
Jonathan L. Finlay, MB, ChB., Study Chair
Girish Dhall, MD.,
Kelley Haley, RN, BSN.,