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Androgen Ablation Therapy With or Without Chemotherapy in Treating Patients With Metastatic Prostate Cancer

Study:

CHAARTED: ChemoHormonal Therapy Versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer [CHAARTED]

Rationale:

Androgens can cause the growth of prostate cancer cells. Androgen ablation therapy may stop the adrenal glands from making androgens. Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether androgen-ablation therapy is more effective with or without docetaxel in treating metastatic prostate cancer.

Purpose:

This randomized phase III trial is studying androgen-ablation therapy and chemotherapy to see how well they work compared to androgen-ablation therapy alone in treating patients with metastatic prostate cancer.

Study Status: Recruiting

Recruiting:
Anjali S. Advani 216-839-3200

Clinical Trials Office - Cleveland Clinic Taussig Cancer Cente 866-223-8100

Clinical Trials Office - Cleveland Clinic Cancer Center at Fai 216-476-9362

Anjali S. Advani 216-524-7979

Anjali S. Advani 440-878-2500

Clinical Trials Office - Cleveland Clinic - Wooster 800-862-7798

Condition Intervention Phase
Prostate Cancer Drug: antiandrogen therapy
Drug: docetaxel		 Phase 3

Verified by Eastern Cooperative Oncology Group December, 2012

Sponsored by: Eastern Cooperative Oncology Group
Information provided by: National Cancer Institute (NCI)
ClinicalTrials.gov identifier: NCT00309985

Study Type: Interventional

Study Design: Allocation: Randomized, Masking: Open Label, Primary Purpose: Treatment

Cleveland Clinic Beachwood Family Health and Surgery Center
Beachwood, Ohio 44122
United States

Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States

Cleveland Clinic Cancer Center at Fairview Hospital
Cleveland, Ohio 44111
United States

Cleveland Clinic Cancer Center
Independence, Ohio 44131
United States

Cleveland Clinic Foundation - Strongsville
Strongsville, Ohio 44136
United States

Cleveland Clinic - Wooster
Wooster, Ohio 44691
United States

Christopher Sweeney, MBBS., Study Chair
David Jarrard, MD.,

This information is abridged to display results relevant only to Cleveland Clinic. To see complete record visit ClinicalTrials.gov
  Information obtained from ClinicalTrials.gov on
Link to the current ClinicalTrials.gov record.