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Assessment of Cardioversion Using Transesophageal Echocardiography II (ACUTE II)


The Use of Enoxaparin Compared to Unfractionated Heparin for Short Term Antithrombotic Therapy in Atrial Fibrillation Patients Undergoing TEE Guided Cardioversion: Assessment of Cardioversion Using Transesophageal Echocardiography (ACUTE) II Randomized Multicenter Study




SPECIFIC AIM: To test the safety and feasibility of using low molecular weight heparin (LMWH, enoxaparin sodium; Lovenox, Sanofi-Aventis) in lieu of unfractionated heparin (UFH) as antithrombotic therapy for patients in atrial fibrillation undergoing transesophageal echocardiography (TEE) guided chemical or electrical cardioversion to sinus rhythm. HYPOTHESIS: Early cardioversion from atrial fibrillation can be safely performed using a short-term anticoagulation strategy of low molecular weight heparin (Lovenox, Sanofi-Aventis) compared to unfractionated heparin, accompanied by a TEE examination prior to cardioversion. The use of LMWH with TEE will result in a safe, cost-effective, and possible efficacious approach to cardioversion of atrial fibrillation compared to UFH with TEE.

Study Status: Completed


Condition Intervention Phase
Atrial Fibrillation Drug: Enoxaparin Phase 4

Verified by The Cleveland Clinic May, 2005

Sponsored by: The Cleveland Clinic
Information provided by: The Cleveland Clinic identifier: NCT00289042

Study Type: Interventional

Study Design: Treatment, Randomized, Open Label, Active Control, Safety/Efficacy Study

Cleveland Clinic
Cleveland, Ohio 44195
United States

Allan L. Klein, MD., Principal Investigator

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