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Azacitidine and Interferon Alfa-2b in Treating Patients With Stage III or Stage IV Melanoma or Stage IV Kidney Cancer That Cannot Be Removed By Surgery


A Phase I Study of 5-Azacitidine in Combination With Interferon-Alfa 2B in Unresectable or Metastatic Melanoma and Renal Cell Carcinoma


Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Interferon alfa-2b may interfere with the growth of tumor cells. Giving azacitadine together with interferon alfa-2b may kill more tumor cells.


This phase I trial is studying the side effects and best dose of interferon alfa-2b when given together with azacitidine in treating patients with stage III or stage IV melanoma or stage IV kidney cancer that cannot be removed by surgery.

Study Status: Active, not recruiting


Condition Intervention Phase
Kidney Cancer
Melanoma (Skin)
Biological: recombinant interferon alfa-2b
Drug: azacitidine
Phase 1

Verified by Yale University November, 2006

Sponsored by: Yale University
Information provided by: National Cancer Institute (NCI) identifier: NCT00217542

Study Type: Interventional

Study Design: Primary Purpose: Treatment

Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States

Mario Sznol, MD., Study Chair

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