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Carotid Stenting vs. Surgery of Severe Carotid Artery Disease and Stroke Prevention in Asymptomatic Patients (ACT I)


Carotid Angioplasty and Stenting Versus Endarterectomy in Asymptomatic Subjects Who Are at Standard Risk for Carotid Endarterectomy With Significant Extracranial Carotid Stenotic Disease (ACT I)




The study is being conducted to demonstrate the non-inferiority of carotid artery stenting (CAS) using the Emboshield® Embolic Protection System with the Xact® Carotid Stent System to carotid endarterectomy (CEA) for the treatment of asymptomatic extracranial carotid atherosclerotic disease.

Study Status: Terminated


Condition Intervention Phase
Carotid Artery Disease
Carotid Stenosis
Device: Carotid artery stenting with filter (interventional)
Procedure: Carotid artery endarterectomy (surgical)
Phase 3

Verified by Abbott Vascular April, 2013

Sponsored by: Abbott Vascular
Information provided by: Abbott Vascular identifier: NCT00106938

Study Type: Interventional

Study Design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label

Cleveland Clinic Foundation
Cleveland, Ohio 44195
United States

Jon Matsumura, MD., Principal Investigator
Kenneth Rosenfield, MD., Principal Investigator

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