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Comparing Angiomax to Heparin With Protamine in Patients Undergoing Cardiopulmonary Bypass (CPB)


A Study Comparing Angiomax (Bivalirudin) to Heparin With Protamine Reversal in Patients Undergoing Cardiac Surgery on Cardiopulmonary Bypass (CPB)




The purpose of this study is to demonstrate that in patients undergoing coronary artery bypass grafting (CABG) or CABG-Valve, or Isolated Cardiac Valve surgery on CPB (cardiac surgery), Angiomax is a safe and effective alternative anticoagulant to heparin with protamine reversal.

Study Status: Completed


Condition Intervention Phase
Cardiovascular Disease
Coronary Artery Bypass Surgery
Drug: Heparin
Drug: Bivalirudin
Phase 3

Verified by The Medicines Company January, 2012

Sponsored by: The Medicines Company
Information provided by: The Medicines Company identifier: NCT00079586

Study Type: Interventional

Study Design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

The Cleveland Clinic
Cleveland, Ohio 44195
United States

Malcolm Lloyd, MD., Study Director

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