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Carboplatin, Vincristine, and Temozolomide in Treating Children With Progressive and/or Symptomatic Low-Grade Glioma


A Pilot Study Using Carboplatin, Vincristine And Temozolomide For Children = 10 Years With Progressive/Symptomatic Low-Grade Gliomas


Drugs used in chemotherapy, such as carboplatin, vincristine, and temozolomide, work in different ways to stop tumor cells from dividing so they stop growing or die. Giving more than one drug may kill more tumor cells.


This pilot study is studying giving carboplatin and vincristine together with temozolomide in treating children with progressive and/or symptomatic low-grade glioma.

Study Status: Active, not recruiting


Condition Intervention Phase
Brain Tumor
Central Nervous System Tumor
Drug: carboplatin
Drug: temozolomide
Drug: vincristine sulfate

Verified by Children`s Oncology Group October, 2013

Sponsored by: Children`s Oncology Group
Information provided by: Children`s Oncology Group identifier: NCT00077207

Study Type: Interventional

Study Design: Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195-5217
United States

Murali M. Chintagumpala, MD., Study Chair

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