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Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer


Phase III Intergroup Trial of Adjuvant Chemoradiation After Resection of Gastric or Gastroesophageal Adenocarcinoma


Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy after surgery may kill any remaining tumor cells following surgery. It is not yet known which chemotherapy and radiation therapy regimen is more effective in treating stomach or esophageal cancer.


Randomized phase III trial to compare two different chemotherapy and radiation therapy regimens in treating patients who have undergone surgery for stomach or esophageal cancer.

Study Status: Active, not recruiting


Condition Intervention Phase
Esophageal Cancer
Gastric Cancer
Drug: cisplatin
Drug: epirubicin hydrochloride
Drug: fluorouracil
Drug: leucovorin calcium
Radiation: radiation therapy
Phase 3

Verified by Cancer and Leukemia Group B April, 2011

Sponsored by: Cancer and Leukemia Group B
Information provided by: Cancer and Leukemia Group B identifier: NCT00052910

Study Type: Interventional

Study Design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Cleveland Clinic Florida - Weston
Weston, Florida 33331
United States

Charles S. Fuchs, MD., Study Chair
Steven R. Alberts, MD., Study Chair
Daniel G. Haller, MD., Study Chair

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