Study:
Phase III Intergroup Trial of Adjuvant Chemoradiation After Resection of Gastric or Gastroesophageal Adenocarcinoma
Rationale:
Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor
cells. Combining chemotherapy with radiation therapy after surgery may kill any remaining
tumor cells following surgery. It is not yet known which chemotherapy and radiation therapy
regimen is more effective in treating stomach or esophageal cancer.
Purpose:
Randomized phase III trial to compare two different chemotherapy and radiation
therapy regimens in treating patients who have undergone surgery for stomach or esophageal
cancer.
Study Status: Active, not recruiting
Recruiting:
n/a
| Condition |
Intervention |
Phase |
Esophageal Cancer
Gastric Cancer |
Drug: cisplatin
Drug: epirubicin hydrochloride
Drug: fluorouracil
Drug: leucovorin calcium
Radiation: radiation therapy |
Phase 3 |
Verified by
Cancer and Leukemia Group B
April, 2011
Sponsored by: Cancer and Leukemia Group B
Information provided by: Cancer and Leukemia Group B
ClinicalTrials.gov identifier: NCT00052910
Study Type: Interventional
Study Design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Cleveland Clinic Florida - Weston
Weston, Florida 33331
United States
Charles S. Fuchs, MD., Study Chair
Steven R. Alberts, MD., Study Chair
Daniel G. Haller, MD., Study Chair