Study:
A Phase III Group-Wide Study of Dose-Intensive Response-Based Chemotherapy and Radiation Therapy for Children and Adolescents With Newly Diagnosed Intermediate Risk Hodgkin Disease
Rationale:
Drugs used in chemotherapy use different ways to stop cancer cells from dividing
so they stop growing or die. Giving the drugs in different combinations may kill more cancer
cells. Radiation therapy uses high-energy x-rays to damage cancer cells. It is not yet known
if chemotherapy is more effective with or without additional chemotherapy and/or radiation
therapy in treating Hodgkin`s disease.
Purpose:
This randomized phase III trial is studying different chemotherapy regimens given
with or without radiation therapy to compare how well they work in treating children with
newly diagnosed Hodgkin`s disease.
Study Status: Completed
Recruiting:
n/a
| Condition |
Intervention |
Phase |
|
Lymphoma |
Biological: bleomycin sulfate
Biological: filgrastim
Drug: cisplatin
Drug: cyclophosphamide
Drug: cytarabine
Drug: dexamethasone
Drug: doxorubicin hydrochloride
Drug: etoposide
Drug: prednisone
Drug: vincristine sulfate
Radiation: radiation therapy |
Phase 3 |
Verified by
Children`s Oncology Group
May, 2013
Sponsored by: Children`s Oncology Group
Information provided by: Children`s Oncology Group
ClinicalTrials.gov identifier: NCT00025259
Study Type: Interventional
Study Design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States
Debra L. Friedman, MD, MS., Study Chair