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Combination Chemotherapy Followed By Donor Bone Marrow or Umbilical Cord Blood Transplant in Treating Children With Newly Diagnosed Juvenile Myelomonocytic Leukemia

Study:

Phase II Window Evaluation of the Farnesyl Transferase Inhibitor (R115777) Followed by 13-CIS Retinoic Acid, Cytosine Arabinoside and Fludarabine Plus Hematopoietic Stem Cell Transplantation in Children With Juvenile Myelomonocytic Leukemia

Rationale:

Giving chemotherapy drugs, such as R115777, isotretinoin, cytarabine, and fludarabine, before a donor bone marrow transplant or an umbilical cord transplant helps stop the growth of cancer cells. It also helps stop the patient`s immune system from rejecting the donor`s stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient`s bone marrow make stem cells, red blood cells, white blood cells, and platelets.

Purpose:

This phase II trial is studying how well giving combination chemotherapy together with donor bone marrow or umbilical cord blood transplant works in treating children with newly diagnosed juvenile myelomonocytic leukemia.

Study Status: Completed

Recruiting:
n/a

Condition Intervention Phase
Leukemia Biological: anti-thymocyte globulin
Drug: cyclophosphamide
Drug: cytarabine
Drug: fludarabine phosphate
Drug: isotretinoin
Drug: tipifarnib
Procedure: allogeneic bone marrow transplantation
Procedure: umbilical cord blood transplantation
Radiation: radiation therapy
Phase 2

Verified by Children`s Oncology Group November, 2010

Sponsored by: Children`s Oncology Group
Information provided by: National Cancer Institute (NCI)
ClinicalTrials.gov identifier: NCT00025038

Study Type: Interventional

Study Design: Primary Purpose: Treatment

Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195-5217
United States

Robert P. Castleberry, MD., Study Chair

This information is abridged to display results relevant only to Cleveland Clinic. To see complete record visit ClinicalTrials.gov
  Information obtained from ClinicalTrials.gov on
Link to the current ClinicalTrials.gov record.

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