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Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing`s Sarcoma


European Ewing Tumour Working Initiative of National Groups Ewing Tumour Studies 1999 (EURO-E.W.I.N.G.99)


Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy and kill more tumor cells. It is not yet known if combination chemotherapy is more effective with or without radiation therapy and/or surgery in treating Ewing`s sarcoma.


This randomized phase III trial is studying different combination chemotherapy regimens to see how well they work when given with or without peripheral stem cell transplantation, radiation therapy, and/or surgery in treating patients with Ewing`s sarcoma.

Study Status: Recruiting

Clinical Trials Office - Cleveland Clinic Taussig Cancer Cente 866-223-8100

Condition Intervention Phase
Sarcoma Biological: dactinomycin
Drug: busulfan
Drug: doxorubicin hydrochloride
Drug: etoposide
Drug: ifosfamide
Drug: melphalan
Drug: vincristine sulfate
Procedure: autologous hematopoietic stem cell transplantation
Procedure: conventional surgery
Radiation: radiation therapy
Phase 3

Verified by University Hospitals, Leicester December, 2011

Sponsored by: University Hospitals, Leicester
Information provided by: National Cancer Institute (NCI) identifier: NCT00020566

Study Type: Interventional

Study Design: Allocation: Randomized, Primary Purpose: Treatment

Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States

Alan W. Craft, MD., Study Chair
Ian J. Lewis, MD., Study Chair
Odile Oberlin, MD., Study Chair
Ian R. Judson, MA, MD, FRCP.,
Heribert F. Juergens, MD., Study Chair
Helmut Gadner, MD, FRCPG., Study Chair
G. Ulrich Exner, MD., Study Chair
Ruth Ladenstein, MD., Study Chair
Douglas Hawkins, MD., Study Chair

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