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Carboxypeptidase-G2 in Treating Nervous System Toxic Effects in Patients Given an Overdose of Intrathecal Methotrexate


A Trial of Carboxypeptidase-G2 (CPDG2) For The Management of Patients With Intrathecal Methotrexate Overdose


Chemoprotective drugs such as carboxypeptidase-G2 may protect normal cells from the toxic effects of chemotherapy.


Clinical trial to study the effectiveness of carboxypeptidase-G2 in treating nervous system toxic effects in patients given an accidental overdose of intrathecal methotrexate.

Study Status: Completed


Condition Intervention Phase
Unspecified Adult Solid Tumor, Protocol Specific
Unspecified Childhood Solid Tumor, Protocol Specific
Drug: glucarpidase N/A

Verified by National Cancer Institute (NCI) April, 2007

Sponsored by: National Cancer Institute (NCI)
Information provided by: National Cancer Institute (NCI) identifier: NCT00018967

Study Type: Interventional

Study Design: Masking: Open Label, Primary Purpose: Supportive Care

Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195-5217
United States

Brigitte C. Widemann, MD., Study Chair

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