Study:
Trial of Chemotherapy Intensification Through Compression in Ewing`s Sarcoma and Related Tumors
Rationale:
Drugs used in chemotherapy work in different ways to stop tumor cells from
dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage
tumor cells. It is not yet known which chemotherapy regimen combined with radiation therapy
and/or surgery is more effective in treating Ewing`s sarcoma or primitive neuroectodermal
tumor.
Purpose:
Randomized phase III trial to compare the effectiveness of different chemotherapy
regimens combined with radiation therapy and/or surgery in treating patients who have
Ewing`s sarcoma or primitive neuroectodermal tumor.
Study Status: Completed
Recruiting:
n/a
| Condition |
Intervention |
Phase |
|
Sarcoma |
Biological: filgrastim
Drug: cyclophosphamide
Drug: doxorubicin hydrochloride
Drug: etoposide
Drug: ifosfamide
Drug: vincristine sulfate
Procedure: adjuvant therapy
Procedure: conventional surgery
Procedure: neoadjuvant therapy
Radiation: brachytherapy
Radiation: radiation therapy |
Phase 3 |
Verified by
Children`s Oncology Group
May, 2013
Sponsored by: Children`s Oncology Group
Information provided by: Children`s Oncology Group
ClinicalTrials.gov identifier: NCT00006734
Study Type: Interventional
Study Design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States
Richard B. Womer, MD., Study Chair