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Comparison of Combination Chemotherapy Regimens in Treating Patients With Ewing`s Sarcoma or Neuroectodermal Tumor


Trial of Chemotherapy Intensification Through Compression in Ewing`s Sarcoma and Related Tumors


Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which chemotherapy regimen combined with radiation therapy and/or surgery is more effective in treating Ewing`s sarcoma or primitive neuroectodermal tumor.


Randomized phase III trial to compare the effectiveness of different chemotherapy regimens combined with radiation therapy and/or surgery in treating patients who have Ewing`s sarcoma or primitive neuroectodermal tumor.

Study Status: Completed


Condition Intervention Phase
Sarcoma Biological: filgrastim
Drug: cyclophosphamide
Drug: doxorubicin hydrochloride
Drug: etoposide
Drug: ifosfamide
Drug: vincristine sulfate
Procedure: adjuvant therapy
Procedure: conventional surgery
Procedure: neoadjuvant therapy
Radiation: brachytherapy
Radiation: radiation therapy
Phase 3

Verified by Children`s Oncology Group May, 2013

Sponsored by: Children`s Oncology Group
Information provided by: Children`s Oncology Group identifier: NCT00006734

Study Type: Interventional

Study Design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States

Richard B. Womer, MD., Study Chair

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