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Biafine Cream to Reduce Side Effects of Radiation Therapy in Patients Receiving Treatment for Advanced Head and Neck Cancer


A Phase III Comparison of Biafine to Declared Institutional Preference for Radiation Induced Skin Toxicity in Patients Undergoing Radiation Therapy for Advanced Squamous Cell Carcinomas of the Head and Neck


Radiation therapy uses high-energy x-rays to damage tumor cells, but may cause skin irritation and inflammation. Biafine cream may be effective in lessening side effects caused by radiation therapy.


Randomized phase III trial to determine the effectiveness of Biafine cream in reducing side effects of radiation therapy in patients receiving treatment for head and neck cancer.

Study Status: Completed


Condition Intervention Phase
Head and Neck Cancer
Skin Reactions Secondary to Radiation Therapy
Drug: Biafine cream
Procedure: quality-of-life assessment
Radiation: radiation therapy
Phase 3

Verified by Radiation Therapy Oncology Group November, 2013

Sponsored by: Radiation Therapy Oncology Group
Information provided by: Radiation Therapy Oncology Group identifier: NCT00006481

Study Type: Interventional

Study Design: Primary Purpose: Supportive Care

Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States

Elizabeth Elliott, MRT(T), MRT(R), CCRP., Study Chair

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