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S0008: Chemotherapy Plus Biological Therapy in Treating Patients With Melanoma


Phase III Trial of High Dose Interferon Alfa 2-b Versus Cisplatin, Vinblastine, DTIC Plus IL-2 and Interferon in Patients With High Risk Melanoma


Interferon alfa may interfere with the growth of cancer cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interleukin-2 may stimulate a person`s white blood cells to kill melanoma cells. It is not yet known whether interferon alfa is more effective with or without combination chemotherapy and interleukin-2 for melanoma.


Randomized phase III trial to compare the effectiveness of interferon alfa with or without combination chemotherapy consisting of cisplatin, vinblastine, and dacarbazine, plus interleukin-2, in treating patients who have melanoma.

Study Status: Completed


Condition Intervention Phase
Melanoma (Skin) Biological: interleukin-2
Biological: filgrastim
Biological: interferon alfa
Drug: cisplatin
Drug: dacarbazine
Drug: vinblastine
Phase 3

Verified by Southwest Oncology Group November, 2012

Sponsored by: Southwest Oncology Group
Information provided by: Southwest Oncology Group identifier: NCT00006237

Study Type: Interventional

Study Design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States

Community Oncology Group at Cleveland Clinic Cancer Center
Independence, Ohio 44131
United States

Cleveland Clinic - Wooster
Wooster, Ohio 44691
United States

Lawrence E. Flaherty, MD., Study Chair
John A. Thompson, MD., Principal Investigator
John T. Vetto, MD, FACS., Principal Investigator
Michael B. Atkins, MD., Study Chair
John M. Kirkwood, MD., Principal Investigator
Frank Haluska, MD, PhD., Study Chair
Alberto S. Pappo, MD., Principal Investigator

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