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Comparison of Three Treatment Regimens in Treating Patients With Relapsed or Refractory Acute Myelogenous Leukemia


A Phase II Randomized Trial of Immunologic and Chemotherapeutic Agents for Treatment of Patients With Relapsed or Refractory Acute Myelogenous Leukemia


Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as gemtuzumab ozogamicin can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. Combining more than one drug or combining monoclonal antibody with chemotherapy may kill more cancer cells. It is not yet known which treatment regimen is more effective for acute myelogenous leukemia.


Randomized phase II trial to compare the effectiveness of three treatment regimens in treating patients who have relapsed or refractory acute myelogenous leukemia.

Study Status: Completed


Condition Intervention Phase
Leukemia Biological: sargramostim
Drug: cyclophosphamide
Drug: cytarabine
Drug: gemtuzumab ozogamicin
Drug: liposomal daunorubicin citrate
Drug: topotecan hydrochloride
Phase 2

Verified by Eastern Cooperative Oncology Group August, 2013

Sponsored by: Eastern Cooperative Oncology Group
Information provided by: Eastern Cooperative Oncology Group identifier: NCT00005962

Study Type: Interventional

Study Design: Allocation: Randomized, Primary Purpose: Treatment

Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States

Mark R. Litzow, MD., Study Chair

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