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Combination Chemotherapy Plus Amifostine in Treating Patients With Advanced Cancer


Phase I Trial of High Dose Chemotherapy Using Amifostine for In-Vivo Protection of GM-CSF Primed Progenitor Cells


Drugs used in chemotherapy use different ways to stop tumors from dividing so they stop growing or die. Chemoprotective drugs, such as amifostine, may protect normal cells from the side effects of chemotherapy.


Phase I trial to study the effectiveness of amifostine plus combination chemotherapy in treating patients with advanced cancer.

Study Status: Active, not recruiting


Condition Intervention Phase
Chronic Myeloproliferative Disorders
Drug/Agent Toxicity by Tissue/Organ
Multiple Myeloma and Plasma Cell Neoplasm
Myelodysplastic Syndromes
Precancerous Condition
Unspecified Adult Solid Tumor, Protocol Specific
Biological: sargramostim
Drug: amifostine trihydrate
Drug: carboplatin
Drug: cyclophosphamide
Phase 1

Verified by The Cleveland Clinic May, 2007

Sponsored by: The Cleveland Clinic
Information provided by: National Cancer Institute (NCI) identifier: NCT00004036

Study Type: Interventional

Study Design: Primary Purpose: Supportive Care

Cleveland Clinic Cancer Center
Cleveland, Ohio 44195
United States

George Thomas Budd, MD., Study Chair

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