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Combination Chemotherapy With or Without Amifostine in Treating Young Patients With Liver Cancer


Intergroup Protocol for Treatment of Children With Hepatoblastoma


Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. Chemoprotective drugs such as amifostine may protect normal cells from the side effects of chemotherapy. It is not yet known which chemotherapy regimen is most effective for children and young adults with liver cancer.


This randomized phase III trial is studying giving combination chemotherapy together with amifostine to see how well it works compared to combination chemotherapy alone in treating patients with liver cancer.

Study Status: Completed


Condition Intervention Phase
Liver Cancer Drug: cisplatin
Drug: fluorouracil
Drug: vincristine sulfate
Procedure: adjuvant therapy
Procedure: conventional surgery
Phase 3

Verified by Children`s Oncology Group November, 2010

Sponsored by: Children`s Oncology Group
Information provided by: National Cancer Institute (NCI) identifier: NCT00003994

Study Type: Interventional

Study Design: Allocation: Randomized, Primary Purpose: Treatment

Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195-5217
United States

Howard M. Katzenstein, MD., Study Chair

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