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Combination Chemotherapy in Treating Patients With Stage III Colon Cancer


Phase III Intergroup Trial of Irinotecan (CPT-11) (NSC# 616348) Plus Luorouracil/Leucovorin (5-FU/LV) Versus Fluorouracil/Leucovorin Alone After Curative Resection for Patients With Stage III Colon Cancer


Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which chemotherapy regimen is more effective for stage III colon cancer.


Randomized phase III trial to compare the effectiveness of fluorouracil plus leucovorin with or without irinotecan in treating patients who have undergone surgery for stage III colon cancer.

Study Status: Completed


Condition Intervention Phase
Colorectal Cancer Drug: FOLFIRI regimen
Drug: fluorouracil
Drug: irinotecan hydrochloride
Drug: leucovorin calcium
Phase 3

Verified by Cancer and Leukemia Group B November, 2012

Sponsored by: Cancer and Leukemia Group B
Information provided by: National Cancer Institute (NCI) identifier: NCT00003835

Study Type: Interventional

Study Design: Allocation: Randomized, Primary Purpose: Treatment

Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States

Leonard B. Saltz, MD., Study Chair
Richard M. Goldberg, MD., Study Chair
David J. Klaassen, MD., Study Chair
Alexander Hantel, MD., Study Chair
James P. Thomas, MD, PhD., Study Chair

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