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Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer


A Randomized Phase III Trial of Three Different Regimens of CPT-11 Plus 5-Fluorouracil and Leucovorin Compared to 5-Fluorouracil and Leucovorin in Patients With Advanced Adenocarcinoma of the Colon and Rectum


Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which regimen of combination chemotherapy is most effective in treating advanced colorectal cancer.


Randomized phase III trial to compare the effectiveness of various combination chemotherapy regimens in treating patients who have advanced, recurrent, or metastatic colorectal cancer that cannot be treated with surgery or radiation therapy.

Study Status: Completed


Condition Intervention Phase
Colorectal Cancer Drug: FOLFOX regimen
Drug: fluorouracil
Drug: leucovorin calcium
Drug: oxaliplatin
Phase 3

Verified by North Central Cancer Treatment Group December, 2011

Sponsored by: North Central Cancer Treatment Group
Information provided by: National Cancer Institute (NCI) identifier: NCT00003594

Study Type: Interventional

Study Design: Allocation: Randomized, Primary Purpose: Treatment

Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States

Henry C. Pitot, MD., Study Chair
Roscoe F. Morton, MD, FACP.,
Charles S. Fuchs, MD., Study Chair
Brian P. Findlay, MD., Study Chair
Ramesh K. Ramanathan, MD., Study Chair
Stephen K. Williamson, MD., Study Chair

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