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Combination Chemotherapy Following GM-CSF in Treating Patients With Multiple Myeloma


Phase II to Treat Multiple Myeloma Patients With Cytoxan and Vincristine After Cycling Myeloma Cells With rHuGM-CSF


Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. GM-CSF may make cancer cells more sensitive to the effects of chemotherapy. Combining more than one drug with GM-CSF may kill more tumor cells.


Phase II trial to study the effectiveness of combination chemotherapy, consisting of cyclophosphamide plus vincristine, following GM-CSF in treating patients with multiple myeloma that has not responded to previous treatment.

Study Status: Completed


Condition Intervention Phase
Multiple Myeloma and Plasma Cell Neoplasm Biological: sargramostim
Drug: cyclophosphamide
Drug: prednisone
Drug: vincristine sulfate
Phase 2

Verified by The Cleveland Clinic March, 2001

Sponsored by: The Cleveland Clinic
Information provided by: National Cancer Institute (NCI) identifier: NCT00003490

Study Type: Interventional

Study Design: Primary Purpose: Treatment

Cleveland Clinic Cancer Center
Cleveland, Ohio 44195
United States

Mohamad A. Hussein, MD., Study Chair

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