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Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin`s Lymphoma


A Randomized Phase III Trial of ABVD Versus Stanford V(+/-) Radiation Therapy in Locally Extensive and Advanced Stage Hodgkin`s Disease Without High Risk Features


Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining more than one drug with radiation therapy may kill more cancer cells. It is not yet known which combination chemotherapy regimen is most effective in treating Hodgkin`s lymphoma.


This randomized phase III trial is studying two different combination chemotherapy regimens and comparing how well they work, with or without radiation therapy, in treating patients with Hodgkin`s lymphoma.

Study Status: Active, not recruiting


Condition Intervention Phase
Lymphoma Biological: bleomycin sulfate
Drug: ABVD regimen
Drug: Stanford V regimen
Drug: cyclophosphamide
Drug: dacarbazine
Drug: doxorubicin hydrochloride
Drug: etoposide
Drug: mechlorethamine hydrochloride
Drug: prednisone
Drug: vinblastine
Drug: vincristine sulfate
Radiation: radiation therapy
Phase 3

Verified by Eastern Cooperative Oncology Group July, 2006

Sponsored by: Eastern Cooperative Oncology Group
Information provided by: Eastern Cooperative Oncology Group identifier: NCT00003389

Study Type: Interventional

Study Design: Allocation: Randomized, Primary Purpose: Treatment

Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States

Community Oncology Group at Cleveland Clinic Cancer Center
Independence, Ohio 44131
United States

Cleveland Clinic - Wooster
Wooster, Ohio 44691
United States

Sandra J. Horning, MD., Study Chair
Richard I. Fisher, MD., Study Chair
Joseph M. Connors, MD., Study Chair
Nancy L. Bartlett, MD., Study Chair

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