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Antifungal Therapy for Fever and Neutropenia in Patients Receiving Treatment for Hematologic Cancer

Study:

A PROSPECTIVE RANDOMIZED, DOUBLE-BLIND, COMPARATIVE, MULTICENTER STUDY TO EVALUATE EFFICACY AND SAFETY OF NYSTATIN AND AMPHOTERICIN B FOR EMPIRIC ANTIFUNGAL TREATMENT IN NEUTROPENIC PATIENTS

Rationale:

Antifungal therapy with liposomal nystatin may reduce fever and neutropenia in patients undergoing treatment for hematologic cancer. It is not yet known whether liposomal nystatin is more effective than standard amphotericin B in treating patients with fever and neutropenia who are receiving chemotherapy for hematologic cancer or bone marrow transplantation for leukemia.

Purpose:

Randomized phase III trial to study the effectiveness of liposomal nystatin compared with standard amphotericin B to treat fever and neutropenia in patients receiving chemotherapy for hematologic cancer or bone marrow transplantation for leukemia.

Study Status: Completed

Recruiting:
n/a

Condition Intervention Phase
Chronic Myeloproliferative Disorders
Infection
Leukemia
Lymphoma
Multiple Myeloma and Plasma Cell Neoplasm
Myelodysplastic Syndromes		 Drug: amphotericin B deoxycholate
Drug: nystatin		 Phase 3

Verified by Aronex Pharmaceuticals July, 2007

Sponsored by: Aronex Pharmaceuticals
Information provided by: National Cancer Institute (NCI)
ClinicalTrials.gov identifier: NCT00002742

Study Type: Interventional

Study Design: Allocation: Randomized, Primary Purpose: Supportive Care

Cleveland Clinic Cancer Center
Cleveland, Ohio 44195
United States

David S. Gordon, MD., Study Chair

This information is abridged to display results relevant only to Cleveland Clinic. To see complete record visit ClinicalTrials.gov
  Information obtained from ClinicalTrials.gov on
Link to the current ClinicalTrials.gov record.