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Recently Released Research
Laser Pulse Application in IVF
In-vitro fertilization (IVF) involves the culture and manipulation of gametes and embryos within a laboratory environment. IVF procedures are channeled towards enhancing fertilization and assisting the normal developmental physiology of the growing embryo to increase implantation potential, culminating in the birth of a healthy baby. Laser and its selective application to various steps in the IVF process is an area of growing interest.
Professional Journal Articles
Below, find a listing of published journal articles, organized by topic:
- »Stem Cells
- Desai N, Xu J, Tsulaia T, Szeptycki-Lawson J, Abdelhafez F, Goldfarb J, Falcone T.2010 Vitrification of mouse embryo-derived ICM cells: a tool for preserving embryonic stem cell potential? J Assist Reprod Genet. 2010 Nov 6. [Epub ahead of print]
- »Embryo Cryopreservation
Desai, N., Abdelhafez, F., Goldberg, J., Falcone, T., and Goldfarb, J., 2010, Clinical pregnancy and live births after transfer of embryos vitrified on Day 3, Reprod Biomed Online 20(6):808-813.
AbdelHafez F, Desai N, Abou-Setta AM, Falcone T, Goldfarb J. Slow freezing, vitrification and ultra-rapid freezing of human embryos: a systematic review and meta-analysis, Reprod Biomed Online 2010 Feb;20(2):209-22. Epub 2009 Nov 27.
Desai N, Szeptycki J, Scott M, AbdelHafez F, Goldfarb J. Artificial Collapse of Blastocysts Before Vitrification: Mechanical vs. Laser Technique and Effect on Survival, Cell Number, and Cell Death in Early and Expanded Blastocysts. Biopreservation and Biobanking 2008; 6(3): 181-190.
Desai N, Blackmon H, Szeptycki J, Goldfarb J. Cryoloop vitrification of human day 3 cleavage-stage embryos: post-vitrification development, pregnancy outcomes and live births. Reprod Biomed Online 2007; 14: 208-213.
Desai N, Goldfarb J. Examination of frozen cycles with replacement of a single thawed blastocyst. Reprod Biomed Online 2005; 11: 349-354.
- »Blastocyst Development/Growth Factors
Desai N, Kattal N, AbdelHafez FF, Szeptycki-Lawson J, Goldfarb J. Granulocyte-macrophage colony stimulating factor (GM-CSF) and co-culture can affect post-thaw development and apoptosis in cryopreserved embryos. J Assist Reprod Genet 2007; 24: 215-222.
Desai N, Lawson J, Goldfarb J. Assessment of growth factor effects on post-thaw development of cryopreserved mouse morulae to the blastocyst stage. Hum Reprod 2000; 15: 410-418.
Desai N, Scarrow M, Lawson J, Kinzer D, Goldfarb J. Evaluation of the effect of interleukin-6 and human extracellular matrix on embryonic development. Hum Reprod 1999; 14: 1588-1592.
Desai NN. The road to blastocyst transfer. Hum Reprod 1998; 13: 3292-3294.
Desai N, Kinzer D, Loeb A, Goldfarb J. Use of Synthetic Serum Substitute and alpha-minimum essential medium for the extended culture of human embryos to the blastocyst stage. Hum Reprod 1997; 12: 328-335.
Desai NN, Sheean LA, Martin D, Gindlesperger V, Austin CM, Lisbonna H, Peskin B, Goldfarb JM. Clinical experience with synthetic serum substitute as a protein supplement in IVF culture media: a retrospective study. J Assist Reprod Genet 1996; 13: 23-31.
- »In Vitro Follicle Maturation
Desai, N., Alex, A., AbdelHafez, F., Calabro, A., Goldfarb, J., Fleischman, A., and Falcone, T., 2010, Three-dimensional in vitro follicle growth: overview of culture models, biomaterials, design parameters and future directions, Reprod Biol Endocrinol 8( Oct 14):119.
Desai, N., Abdelhafez, F., Ali, M. Y., Sayed, E. H., Abu-Alhassan, A. M., Falcone, T., and Goldfarb, J., 2010, Mouse ovarian follicle cryopreservation using vitrification or slow programmed cooling: Assessment of in vitro development, maturation, ultra-structure and meiotic spindle organization, J Obstet Gynaecol Res July 15(ePub, ahead of print)).
- »Embryonic Markers and Scoring
Desai N, Filipovits J, Goldfarb J. Secretion of soluble HLA-G by day 3 human embryos associated with higher pregnancy and implantation rates: assay of culture media using a new ELISA kit. Reprod Biomed Online 2006; 13: 272-277.
Desai NN, Goldstein J, Rowland DY, Goldfarb JM. Morphological evaluation of human embryos and derivation of an embryo quality scoring system specific for day 3 embryos: a preliminary study. Hum Reprod 2000; 15: 2190-2196.
- »Testicular Sperm / Single Sperm Cryopreservation
AbdelHafez F, Bedaiwy M, El-Nashar SA, Sabanegh E, Desai N. Techniques for cryopreservation of individual or small numbers of human spermatozoa: a systematic review. Hum Reprod Update 2009; 15: 153-164.
French DB, Sabanegh ES, Jr., Goldfarb J, Desai N. Does severe teratozoospermia affect blastocyst formation, live birth rate, and other clinical outcome parameters in ICSI cycles? Fertil Steril 2009 [Epub ahead of print].
Desai, N., AbdelHafez1, F., Sabanegh, E., Goldfarb, J., 2009, Paternal effect on genomic activation, clinical pregnancy and live birth rate after ICSI with cryopreserved epididymal versus testicular spermatozoa, Reproductive Biology and Endocrinology 2009, 7:142
Desai NN, Blackmon H, Goldfarb J. Single sperm cryopreservation on cryoloops: an alternative to hamster zona for freezing individual spermatozoa. Reprod Biomed Online 2004; 9: 47-53.
- »Fertility Preservation
Desai, N., AbdelHafez, F., Drazba, J., Goldfarb, J., Falcone, T., 2010, A simple and efficient method for preparation of isolated ovarian follicles for transmission electron microscopy, J Assist Reprod Genet DOI 10.1007/s10815-010-9389-4
AbdelHafez F, Desai N, Ali MY, Sayed EH, Abu-Alhassan AM, Bedaiwy MA. Oocyte Cryopreservation: a Technical and Clinical Update. Expert Review of Obstetrics & Gynecology 2009; 4(4): 443-453.
Bedaiwy MA, El-Nashar SA, El Saman AM, Evers JL, Sandadi S, Desai N, Falcone T. Reproductive outcome after transplantation of ovarian tissue: a systematic review. Hum Reprod 2008; 23: 2709-2717.
- »Coculture of Embryos
Desai N, Abdelhafez F, Bedaiwy MA, Goldfarb J. Live births in poor prognosis IVF patients using a novel non-contact human endometrial co-culture system. Reprod Biomed Online 2008; 16: 869-874.
Desai N, Goldfarb J. Co-cultured human embryos may be subjected to widely different microenvironments: pattern of growth factor/cytokine release by Vero cells during the co-culture interval. Hum Reprod 1998; 13: 1600-1605.
Desai NN, Goldfarb JM. Growth factor/cytokine secretion by a permanent human endometrial cell line with embryotrophic properties. J Assist Reprod Genet 1996; 13: 546-550.
- »Additional Publication Topics
Desai N, Austin C, AbdelHafez F, Goldfarb J, Falcone T. Evidence of 'genuine empty follicles' in follicular aspirate: a case report. Hum Reprod 2009; 24: 1171-1175.
Goldfarb JM, Fisher NL, Gillespie L, Austin CM, Lisbona H, Peskin BD, Desai N. Partnership for Families Program: philanthropy for in vitro fertilization patients. J Reprod Med. 2009 Sep;54(9):548-52.
Goldfarb JM, Desai N. Follitropin-alpha versus human menopausal gonadotropin in an in vitro fertilization program. Fertil Steril 2003; 80: 1094-1099.
Goldfarb JM, Desai N. Clinical experience reported as a retrospective study. Fertil Steril 2003; 80: 1123.
Goldfarb JM, Desai N. The spectrum of embryo transfer days. Fertil Steril 2002; 78: 887; author reply 887.
Goldfarb JM, Austin C, Peskin B, Lisbona H, Desai N, de Mola JR.Fifteen years experience with an in-vitro fertilization surrogate gestational pregnancy programme. Hum Reprod 2000; 15: 1075-1078.
Goldfarb JM, Desai N. The spectrum of embryo transfer days. Fertil Steril 2002; 78: 887; author reply 887.
Goldfarb JM, Austin C, Peskin B, Lisbona H, Desai N, de Mola JR. Fifteen years experience with an in-vitro fertilization surrogate gestational pregnancy programme. Hum Reprod 2000; 15: 1075-1078.