- »Ask Children (Assess Specific Kinds of Children Challenges in Neurology Devices) (09-555)
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Primary Investigator: Dr. Neil Friedman 216.444.6772
This study sponsored by the FDA will evaluate scientific and medical issues pertaining to children undergoing treatment with a medical device . The ASK CHILDREN study is intended to aid in future development of various prostheses. The FDA seeks to use the information obtained to identify more efficient strategies in the evaluation and review of these devices regulated by the Agency. This study will focus primarily on children ages 7-15 with neurological devices such as VP shunt, the Cochlear implant, DBS for dystonia, Spinal Cord stimulator post spinal cord injury, VNS for epilepsy.
- »VIPS Study (09-850)
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Primary Investigator: Dr. Neil Friedman 216.444.6772
Vascular effects of infection in pediatric stroke.
The purpose of the study is to examine the association between infection and arterial ischemic stroke (AIS) in children aged 1 month to the 19th birthday, 480 will be enrolled over three years at 25 sites.
- »Zomig Study
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Primary Investigator: Dr. David Rothner 216.444.5514
A Multicenter, Double-blind, Randomized, Placebo-controlled, 4-Armed Parallel Group Study to Evaluate the Efficacy of Zolmitriptan 0.5-, 2.5- and 5-mg Nasal Spray in the Treatment of Acute Migraine Headache in Adolescents. Male and female adolescent patients, Age 12 to 17 years, With an established diagnosis of migraine.
The primary objective of this study is to compare the efficacy of zolmitriptan nasal spray 0.5, 2.5, and 5 mg with placebo in the acute treatment of migraine headache in adolescents (aged 12 to 17), as measured by the primary outcome variable of pain-free status at 2 hours post treatment.
- »Natural History of Duchene Muscular Dystrophy Patients on Corticosteroids that Best Describes Decline in Function and Strength (IRB #09-969)
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Primary Investigator: Dr. Neil Friedman 216.444.6772
The objective is to identify the most powerful outcomes measures for DMD patients on corticosteroids that best describes decline in function and strength.
- »Incidence and Follow Up of New Daily Persistent Headaches in Children and Adolescents (08-792)
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Primary Investigator: Dr. David Rothner 216.444.5514
- Collect data from a large group of adolescents with NDPH
- Stratify data by age and sex
- Review data for predisposing conditions, pre-existing headaches, description of current headache and co-existing problems
- Analyze if diagnostic studies, such as blood tests, MRI, etc. are of any significant value (5) Record proposed treatment and outcomes with follow up of current condition of the headache.
- »Neurofibromatosis Data Base (09-676)
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Primary Investigator: Dr. Manikum Moodley and Dr David Rothner
Study Coordinator: Donna Carter 216.445.5579
- »Childhood Stroke (7379)
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Primary Investigator: Dr. Neil Friedman 216.444.6772
Review demographics,stroke subtypes, investigations and treatment of childhood stroke.
- »Pediatric Stroke Registry (7638)
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Primary Investigator: Dr. Neil Friedman 216.444.6772
To establish a Pediatric Stroke Registry within Northeast Ohio.
- »The Pompe Registry (IRB # 09-904)
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Primary Investigator: Dr. Gary Hsich 216.444.4899
The Pompe Registry is an ongoing, observational program sponsored by Genzyme that tracks the natural history and outcomes of patients with Pompe disease. Participation is open to all physicians managing patients with Pompe disease. Physicians are encouraged to collaborate, share observations, generate hypotheses for evaluation and assist in the collection of clinical data in an effort to guide and assess future therapeutic interventions. The Pompe Registry was established to better understand the variability and progression of Pompe disease and to continue to monitor and evaluate treatments.
- »Height and Weight in Children with Tourette Syndrome (06-638)
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Primary Investigator: Dr. Debabrata Ghosh 216.444.1109
To find out whether the children withTourette syndrome are bigger and heavier when compared with normal children.
- »Retrospective Study of the Children with Cerebral Venous Sinus Thrombosis Associated with Otitis Media (08-862)
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Primary Investigator: Dr. Debabrata Ghosh 216.444.1109
To find out how common is the occurrence of cerebral venous sinus thrombosis in the setting of otitis media in children in our hospital setting.
- »Subdural Hematoma Complicating Benign External Hydrochphalus in Children (08-863)
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Primary Investigator: Dr. Debabrata Ghosh 216.444.1109
- To find the frequency of occurence of subdural hematoma in children with benign external hydrocephalus.
- To find out any specific reason to explain development of subdural hematoma in those children.
- To find out the clinical, investigation results and Prognosis in these children on follow up.
- »Posterior Reversible Encephalopathy Syndrome (PRES) in 3 Children (08-928)
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Primary Investigator: Dr. Manikum Moodley 216.444.3135
To delineate clinical profile, MRI findings and management of three children with posterior reversible encephalopathy syndrome (PRES).
- »Neuromylitis Optica (NMO) in Children (09-185)
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Primary Investigator: Dr. Manikum Moodley 216.444.3135
To report varied clinical characteristics associated with NMO antibody in pediatric patients.
- »Intercranial Complications of Sinusitis in Children. (09-581)
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Primary Investigator: Dr. Manikum Moodley 216.444.3135
A 10 year retrospective chart review of children admitted to the Cleveland Clinic with a diagnosis of sinusitis.
- »Relationship Between Vaccinations and Preceeding Illnesses to Neuromylitis Optica and other Demyelinating Disorders (09-634)
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Primary Investigator: Dr. Ngoc Minh Le and Dr. Manikum Moodley 216.444.3135
Looking at the correlation between vaccination and prior infections to NMO and other demylinating disorders.
- »Retrospective Study of the Neurologic Comorbidities Associated with Children with Downs Syndrome (09-634)
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Dr. Ninon Pachikara and Dr. Manikum Moodley 216.444.3135
A chart review of children seen at the Cleveland Clinic over the past 10 years looking at neurologic conditions associated with downs syndrome.
- »Headache in Children and Adolescents with Neurofibromatosis Type 1 (09-601)
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Primary Investigator: Dr. David Rothner 216.444.5514
It is a goal of this study to provide more knowledge and increase awareness among clinicians of the relationship between headache and NF-1.
- »Outcomes of Epilepsy Surgery in Children with Poorly Localized Preoperative Ictal and Iinterictal EEG (8604)
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Primary Investigator: Dr. Elaine Wyllie
The purpose of this study is to discover the outcome of Epilepsy surgery on children with poorly localized pre-op Ictal -interectal EEG.
- »Autism Standards Project
- Primary Investigator: Dr. Sumit Parikh 216.444.1994
Developing standards for diagnostic evaluation and medical/psychological care of all patients with autism. Prospective data collection.
- »Transverse Myelitis
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Primary Investigator: Dr. Manikum Moodley 216.444.3135
A retrospective review of children less than 21 years of age with acute transverse myletis
- »Children with Atypical Teratoid Rhabdoid Tumors (09-1070)
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Primary Investigator: Dr. Manikum Moodley 216.444.3135
A 20 retrospective review of the historical clinical, investigations, management and outcomes of children less than 18 years of age admitted to the Cleveland clinic childrens hospital with atypical teratoid rhabdoid.
- »Children with NF1, A 20 Year Retrospective Review (09-1061)
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Primary Investigator: Dr. Manikum Moodley 216.444.3135
A retrospective review of patients with NF1seen over a 20 year period with abnormalities of the brainstem, basil ganglia, and cerebellum.