Our laboratory studies the potential treatment of spinal cord injury using nerve regeneration strategies and neurorehabilitation approaches to restore functional recovery. Pathological changes at spinal cord injury site creates non-permissive environment for axonal regeneration. The key leads to regain functional recovery are to encourage more axons to cross the damaged site and have proper connection with target neurons. A major focus is using peripheral nerve transplantation with growth factors, artificial conduits, and also combining other cellular transplantation or rehabilitation methods to promote systematic recovery such as motor, sensory, skeletal muscles, and autonomic function after spinal cord injury. Another project area is focused on the problems of post traumatic stress disorder, hearing, and autonomic disorders after traumatic brain injury and the potential solutions for these problems.
Current projects and funding
The bladder recovery after spinal cord injury (NIH/NINDS R01 grant) Traumatic brain injury and autonomic disorders.
Magnetic stimulation and Seizure
- Lee, Y-S., H. Ian and V. Lin. Peripheral nerve graft and aFGF restore partial hindlimb function in adult paraplegic rats. J. Neurotrauma. 19, 1203-1216, 2002.
- Cheng, H. and Lee, Y.-S. Spinal cord repair strategies. pp 801-816. (2003) V. W. Lin. Spinal cord medicine: principles and practice. Demos Medical Publishing, Inc. New York, N.Y.
- Vaziri, N. D., Y.-S. Lee, C.-Y. Lin, V. W. Lin and R. K. Sindhu. NAD(P)H oxidase, superoxide dismutase, catalase, glutathione peroxidase and nitric oxide synthase expression in subacute spinal cord injury. Brain Research. 995: 76-83, 2004.
- Lee, Y.-S., C.-Y. Lin, R. T. Robertson, I. Hsiao and V. W. Lin. Motor recovery and anatomical evidence of axonal re-growth in spinal cord repaired adult rats. J. Neuropathology and Experimental Neurology. 63: 233-245, 2004.
- Lee, Y.-S., R. K. Sindhu, C.-Y. Lin, V. W. Lin and N. D. Varziri. Effect of nerve graft on nitric oxide synthetase, NAD(P)H oxidase, and antioxidant enzyme in chronic spinal cord injury. Free Radical Biology and Medicine 36: 330-339, 2004.
- Lin, V.W., I. Hsiao, X. Deng, Y.-S. Lee, S. Sasse. Functional magnetic ventilation in dogs. Archives of Physical Medicine and Rehabilitation 85: 1493-1498, 2004.
- Lee, Y.-S., C.-Y. Lin, R. T. Robertson, J. Yu, X.M. Deng, I. Hsiao and V. W. Lin. Re-growth of catecholaminergic fibers and protection of cholinergic spinal cord neurons in spinal repaired rats. European Journal of Neuroscience 23: 693-702, 2006.
- Lee, Y.-S., C.-Y. Lin, V.J. Caiozzo, Richard T. Robertson, and V.W. Lin. Repair of spinal cord transection and its effects on muscle mass and myosin heavy chain isoform phenotype. Journal of Applied Physiolog, 103: 1808-1814, 2007.
- Lin, V.W., X. Deng, Y.-S. Lee, I. Hsiao. Stimulation of the expiratory muscles using microstimulators. IEEE Trans Neural Syst Rehabil Eng. 16: 416-420, 2008.
- Lee, Y.-S., S. Zdunowski, V.R. Edgerton, R. Roy, H. Zhong, I. Hsiao, and V.W. Lin. Improvement of gait patterns in step-trained, complete spinal cord transected rats treated with peripheral nerve graft and acidic fibroblast growth factor. Experimental Neurology 224(2): 429-437, 2010.